| Sequential changes of longitudinal and radial myocardial deformation indices in the healthy neonate heart. | |
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MedLine Citation:
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PMID: 20138471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Significant hemodynamic changes, including preload and afterload modifications, occur during the transition from the fetal to the neonatal environment. The ductus arteriosus closes, pulmonary vascular resistance decreases, and pulmonary blood flow increases. Strain rate (SR) and strain (epsilon) have been proposed as ultrasound indices for quantifying regional wall deformation. This study was designed to determine if these indices can detect variations in regional deformation between early and late neonatal periods. METHODS: Data were obtained from 30 healthy neonates (15 male). The initial study was performed at a mean age of 20.1+/-14 hours (exam 1) and the second at 31.9+/-2.9 days (exam 2). Apical and parasternal views were used to quantify regional left ventricular (LV) and right ventricular (RV) longitudinal and radial SR and epsilon, and systolic, early, and late diastolic values were calculated from these curves. A paired-samples t test was performed comparing the two groups. RESULTS: Compared with exam 1, LV radial deformation showed significant reductions in peak systolic epsilon in the basal and mid segments (51+/-15% vs 46+/-9%, P<.01). LV longitudinal deformation behaved similarly, showing significant peak systolic epsilon reductions in all measured segments. Systolic SR showed reductions only in the basal and apical segments of the lateral wall and in the mid portion of the inferior wall (-1.9+/-0.5 vs -1.7+/-0.3 s(-1) and -1.9+/-0.4 vs -1.7+/-0.2 s(-1), respectively, P=.03). RV longitudinal free and inferior wall systolic SR and epsilon values were significantly higher in exam 2. CONCLUSIONS: LV peak systolic epsilon decreases in exam 2 were possibly due to afterload increase and preload decrease. The lower RV initial deformation indices could be attributed to increased afterload caused by physiologic pulmonary hypertension or immature RV contractile properties. SR seemed to be a more robust index than epsilon and less influenced by preload and afterload hemodynamic alteration. |
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Authors:
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Jos? Luiz Barros Pena; Marconi Gomes da Silva; Jos? Mariano Sales Alves; Vera Maria Cury Salemi; Charles Mady; Aigul Baltabaeva; George R Sutherland |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 23 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 294-300 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Heart Institute (InCor) USP, S?o Paulo, Brazil. jlpena.bh@terra.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Elastic Modulus
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physiology Elasticity Imaging Techniques / methods* Female Fetal Heart / physiology*, ultrasonography* Humans Image Interpretation, Computer-Assisted / methods* Infant, Newborn Reproducibility of Results Sensitivity and Specificity Ultrasonography, Prenatal / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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