| ?Sequential? Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model. | |
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MedLine Citation:
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PMID: 21294607 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract In the present study the therapeutic effect and potential toxicity of the novel ?Sequential? boron neutron capture therapy (Seq-BNCT) for the treatment of oral cancer was evaluated in the hamster cheek pouch model at the RA-3 Nuclear Reactor. Two groups of animals were treated with ?Sequential? BNCT, i.e., BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24?h (Seq-24h-BNCT) or 48?h (Seq-48h-BNCT) later. In an additional group of animals, BPA and GB-10 were administered concomitantly [(BPA + GB-10)-BNCT]. The single-application BNCT was to the same total physical tumor dose as the ?Sequential? BNCT treatments. At 28?days post-treatment, Seq-24h-BNCT and Seq-48h-BNCT induced, respectively, overall tumor responses of 95 ? 2% and 91 ? 3%, with no statistically significant differences between protocols. Overall response for the single treatment with (BPA + GB-10)-BNCT was 75 ? 5%, significantly lower than for Seq-BNCT. Both Seq-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in the dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47 ? 12% and 60 ? 22% of the animals, respectively. No normal tissue toxicity was associated with tumor response for any of the protocols. ?Sequential? BNCT enhanced tumor response without an increase in mucositis in normal tissue or dose-limiting precancerous tissue. |
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Authors:
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Ana J Molinari; Emiliano C C Pozzi; Andrea Monti Hughes; Elisa M Heber; Marcela A Garabalino; Silvia I Thorp; Marcelo Miller; Maria E Itoiz; Romina F Aromando; David W Nigg; Jorge Quintana; Gustavo A Santa Cruz; Ver Nica A Trivillin; Amanda E Schwint |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-4 |
Journal Detail:
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Title: Radiation research Volume: - ISSN: 1938-5404 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Department of Radiobiology, Constituyentes Atomic Center, National Atomic Energy Commission, Argentina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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