Document Detail

Sequencing surgery, radiotherapy and chemotherapy: insights from a mathematical analysis.
MedLine Citation:
PMID:  12206517     Owner:  NLM     Status:  MEDLINE    
We present results from a mathematical analysis that is aimed at finding the best way to sequence the three traditional cancer treatments: surgery (S), chemotherapy (C), and radiotherapy (R). The mathematical model tracks the temporal evolution of the primary tumor and its associated metastases, and incorporates the primary tumor's effect on the dormancy and growth of the metastases. We show that the SCR schedule (i.e., surgery followed by chemotherapy followed by radiotherapy) achieves a higher cure probability than SRC if the primary tumor is sufficiently large or if the metastatic population is sufficiently large relative to the primary tumor. We also show that a novel schedule, SRCR, which splits the radiotherapy regimen into two disjoint portions, is optimal among all schedules, provided that the patient's dormant metastatic tumors do not become vascularized within about 40 days after surgery.
Damian R Beil; Lawrence M Wein
Related Documents :
14998677 - Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: earl...
6399987 - Implantable devices for chronic access and drug delivery to the central nervous system.
17356247 - Liver metastasis four years after whipple's resection for solid-pseudopapillary tumor o...
3868327 - Cell kinetic studies of the effect of cytotoxic drugs on survival and proliferation of ...
25347297 - Correction: despr roles in tumor vasculo-angiogenesis, invasiveness, csc-survival and a...
2457457 - Failure of the viable yellow (avy) and lethal yellow (ay) genes to enhance chemical ind...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Breast cancer research and treatment     Volume:  74     ISSN:  0167-6806     ISO Abbreviation:  Breast Cancer Res. Treat.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2003-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111104     Medline TA:  Breast Cancer Res Treat     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
Operations Research Center, Massachusetts Institute of Technology, Cambridge 02139, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast Neoplasms / drug therapy,  radiotherapy,  surgery,  therapy*
Decision Support Techniques*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association between nitrotyrosine levels and microvascular density in human breast cancer.
Next Document:  An in vitro study of the reduction in wear of metal-on-metal hip prostheses using surface-engineered...