Document Detail


Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization.
MedLine Citation:
PMID:  17284678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eimeria tenella is an intracellular protozoan parasite that infects the intestinal tracts of domestic fowl and causes coccidiosis, a serious and sometimes lethal enteritis. Eimeria falls in the same phylum (Apicomplexa) as several human and animal parasites such as Cryptosporidium, Toxoplasma, and the malaria parasite, Plasmodium. Here we report the sequencing and analysis of the first chromosome of E. tenella, a chromosome believed to carry loci associated with drug resistance and known to differ between virulent and attenuated strains of the parasite. The chromosome--which appears to be representative of the genome--is gene-dense and rich in simple-sequence repeats, many of which appear to give rise to repetitive amino acid tracts in the predicted proteins. Most striking is the segmentation of the chromosome into repeat-rich regions peppered with transposon-like elements and telomere-like repeats, alternating with repeat-free regions. Predicted genes differ in character between the two types of segment, and the repeat-rich regions appear to be associated with strain-to-strain variation.
Authors:
King-Hwa Ling; Marie-Adele Rajandream; Pierre Rivailler; Alasdair Ivens; Soon-Joo Yap; Alda M B N Madeira; Karen Mungall; Karen Billington; Wai-Yan Yee; Alan T Bankier; Fionnadh Carroll; Alan M Durham; Nicholas Peters; Shu-San Loo; Mohd Noor Mat Isa; Jeniffer Novaes; Michael Quail; Rozita Rosli; Mariana Nor Shamsudin; Tiago J P Sobreira; Adrian R Tivey; Siew-Fun Wai; Sarah White; Xikun Wu; Arnaud Kerhornou; Damer Blake; Rahmah Mohamed; Martin Shirley; Arthur Gruber; Matthew Berriman; Fiona Tomley; Paul H Dear; Kiew-Lian Wan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-06
Journal Detail:
Title:  Genome research     Volume:  17     ISSN:  1088-9051     ISO Abbreviation:  Genome Res.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-04-05     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9518021     Medline TA:  Genome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosome Mapping
Chromosome Structures / genetics*
Computational Biology
Eimeria tenella / genetics*
Genes, Protozoan / genetics*
Minisatellite Repeats / genetics
Molecular Sequence Data
Polymorphism, Restriction Fragment Length
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
MC_U105131672//Medical Research Council; //Wellcome Trust
Comments/Corrections

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