| Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. | |
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MedLine Citation:
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PMID: 10520737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Through the sequencing of a 42kb cosmid clone we describe a new gene, designated PEREC1, located approximately 1.5kb centromeric of the human apolipoprotein (APO) E-C2 cluster. The combination of dotplot analysis, predicted coding potential and interrogation of the Expressed Sequence Tag (EST) database determined the genomic organisation of PEREC1. Sequence alignment with multiple overlapping ESTs confirmed the predicted splice sites. The predicted cDNA and amino acid sequences of PEREC1 have extensive similarity to the Caenorhabditis elegans protein, C18E9.6. Conserved structural and functional motifs have been defined by combining nucleotide and amino acid analyses to identify third base degeneracy and therefore selection at the protein level. The Poliovirus Receptor Related Protein2 gene (PRR2), previously mapped to chromosome 19q13.2 by Fluorescent In-Situ Hybridisation, has also been located approximately 17kb centromeric of APO E. |
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Authors:
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E M Freitas; W J Zhang; J P Lalonde; G K Tay; S Gaudieri; L K Ashworth; F M Van Bockxmeer; R L Dawkins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: DNA sequence : the journal of DNA sequencing and mapping Volume: 9 ISSN: 1042-5179 ISO Abbreviation: DNA Seq. Publication Date: 1998 |
Date Detail:
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Created Date: 1999-12-09 Completed Date: 1999-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107800 Medline TA: DNA Seq Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 89-100 Citation Subset: IM |
Affiliation:
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Centre for Molecular Immunology and Instrumentation, University of Westem Australia, Nedlands. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AB012576 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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genetics Amino Acid Motifs Amino Acid Sequence Animals Apolipoproteins E / chemistry*, genetics* Base Sequence Caenorhabditis elegans / genetics Cell Adhesion Molecules Chromosome Mapping Chromosomes, Human, Pair 19 / genetics Coronary Disease / genetics Cosmids / genetics Databases, Factual Expressed Sequence Tags Helminth Proteins / chemistry, genetics Humans Membrane Glycoproteins / chemistry, genetics Membrane Transport Proteins* Molecular Sequence Data Multigene Family* Proteins / chemistry, genetics*, metabolism Receptors, Tumor Necrosis Factor* Receptors, Tumor Necrosis Factor, Member 14 Receptors, Virus* Sequence Analysis, DNA Sequence Analysis, Protein |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Cell Adhesion Molecules; 0/Helminth Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Proteins; 0/Receptors, Tumor Necrosis Factor; 0/Receptors, Tumor Necrosis Factor, Member 14; 0/Receptors, Virus; 0/TNFRSF14 protein, human; 0/TOMM40 protein, human; 0/nectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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