| Sequence variations of hepatitis B virus promoter regions in persistently infected patients. | |
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MedLine Citation:
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PMID: 11315638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The HBV in the sera of two chronic active hepatitis patients were analyzed for the promoter sequence heterogeneity. In most cases, the proportion of any particular clone in the total viral populations was less than 50%, showing high mutation rates. In contrast, promoter sequences of HBV from asymptomatic carriers revealed only a few point mutations with no deletions. HBV in chronic patient harbored variants with multiple mutations throughout promoters including 1762 (A-to-T), 1764 (G-to-A) double mutation in C promoter and deletions near CCAAT site in S promoter. Unlike other three promoter regions, C, pre-S1 and S, of HBV which revealed a high level of sequence heterogeneity, the X promoter region (from nt985 to 1430) showed little sequence heterogeneity within a patient. However, the predominant viral clones in two patients were quite different from each other. In addition to mutations in promoter regions, a deletion mutation in the translation start codon was also found in pre-S1 gene. The results in this report indicate that the mutation rates are not the same in all four promoters and that one of the strategies for maintaining persistent infection could be through mutations in viral promoters which then impair the balance of viral gene expressions. |
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Authors:
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Y M Ha-Lee; J Lee; H Pyun; Y Kim; J Sohn; Y J Cho; Y Kim |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of virology Volume: 146 ISSN: 0304-8608 ISO Abbreviation: Arch. Virol. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-04-23 Completed Date: 2001-05-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7506870 Medline TA: Arch Virol Country: Austria |
Other Details:
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Languages: eng Pagination: 279-92 Citation Subset: IM |
Affiliation:
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Korea Nutrition Research Institute, Korea University, Seoul, Korea. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF276519; AF276520; AF276521; AF276522; AF276523; AF276524; AF276525; AF276526; AF276527; AF276528; AF276529; AF276530; AF276531; AF276532; AF276533; AF276534; AF276535; AF276536; AF276537; AF276538; AF276539; AF276540; AF276541; AF276542; AF276543; AF276544; AF276545; AF276546; AF276547; AF276548; AF276549; AF276550; AF276551; AF276552; AF276553; AF276554; AF276555; AF276556; AF276557; AF276558; AF276559; AF276560; AF276561; AF276562; AF276563; AF276564; AF276565; AF276566; AF276567; AF276568; AF276569; AF276570; AF276571; AF276572; AF276573; AF276574; AF276575; AF276576; AF276577; AF276578; AF276579; AF276580; AF276581; AF276582; AF276583; AF276584; AF276585; AF276586; AF276587; AF276588; AF276589; AF276590; AF276591; AF276592; AF276593; AF276594; AF276595; AF276596; AF276597; AF276598; AF276599; AF276600; AF276601; AF276602; AF276603; AF276604; AF276605; AF276606; AF276607; AF276608; AF276609; AF276610; AF276611; AF276612; AF276613; AF276614; AF276615; AF276616 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Base Sequence Cloning, Molecular DNA, Viral / genetics Female Genetic Variation* Hepatitis B virus / genetics*, isolation & purification Hepatitis B, Chronic / blood, virology* Humans Male Middle Aged Molecular Sequence Data Mutation* Mutation, Missense Polymerase Chain Reaction Promoter Regions, Genetic* Sequence Deletion |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
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