| Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor. | |
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MedLine Citation:
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PMID: 2890159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. The former includes a signal peptide of about 21 residues and an NH2-terminal propeptide of 30 amino acids. GIP is released from the precursor by processing at single arginine residues. There is a region of nine amino acids in the COOH-terminal propeptide of the GIP precursor that has partial homology with a portion of chromogranin A as well as pancreastatin. |
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Authors:
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J Takeda; Y Seino; K Tanaka; H Fukumoto; T Kayano; H Takahashi; T Mitani; M Kurono; T Suzuki; T Tobe |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 84 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-11-25 Completed Date: 1987-11-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 7005-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kyoto University School of Medicine, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/M18185 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Chromogranin A Chromogranins / genetics DNA / genetics* Duodenum / analysis Gastric Inhibitory Polypeptide / genetics* Molecular Sequence Data Pancreatic Hormones / genetics Poly A / genetics Protein Precursors / genetics* Protein Sorting Signals / genetics RNA, Messenger / genetics Sequence Homology, Nucleic Acid |
| Chemical | |
Reg. No./Substance:
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0/Chromogranin A; 0/Chromogranins; 0/Pancreatic Hormones; 0/Protein Precursors; 0/Protein Sorting Signals; 0/RNA, Messenger; 106477-83-2/pancreastatin; 24937-83-5/Poly A; 59392-49-3/Gastric Inhibitory Polypeptide; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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