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Sequence of an expressed human beta-tubulin gene containing ten Alu family members.
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MedLine Citation:
PMID:  6462917     Owner:  NLM     Status:  MEDLINE    
The complete sequence of a functionally expressed human beta-tubulin gene (5 beta) is presented. The amino acid sequence encoded by this gene constitutes a distinct isotype, differing from a previously described human beta-tubulin sequence at 21 positions throughout the polypeptide chain. The beta-tubulin coding sequence in 5 beta is interrupted by three intervening sequences of 1014, 117 and 4826 nucleotides. The largest of these contains ten members of the Alu family of middle repetitive sequences. Together, these regions account for sixty percent of this intervening sequence. Two of the Alu elements are juxtaposed head to tail, and share the same flanking direct repeat. The ten Alu sequences are substantially divergent, both from each other and from an Alu consensus sequence, and several contain deletions of up to half the entire sequence.
M G Lee; C Loomis; N J Cowan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nucleic acids research     Volume:  12     ISSN:  0305-1048     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-17     Completed Date:  1984-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5823-36     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Base Sequence
Gene Expression Regulation
Repetitive Sequences, Nucleic Acid*
Tubulin / genetics*
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Full Text
Journal Information
Journal ID (nlm-ta): Nucleic Acids Res
ISSN: 0305-1048
ISSN: 1362-4962
Article Information
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Print publication date: Day: 25 Month: 7 Year: 1984
Volume: 12 Issue: 14
First Page: 5823 Last Page: 5836
ID: 320034
PubMed Id: 6462917

Sequence of an expressed human beta-tubulin gene containing ten Alu family members.
M G Lee
C Loomis
N J Cowan

Article Categories:
  • Research Article

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