| Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel. | |
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MedLine Citation:
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PMID: 11595125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the sequence dependency of antitumor efficacy and toxicity in combination therapy of nedaplatin (NDP) with paclitaxel (TXL) against Lewis lung carcinoma. The sequential administration of NDP prior to TXL (NT therapy) resulted in severe body weight loss followed by frequent toxic death of mice. In contrast, the sequential dosing of TXL prior to NDP (TN therapy) resulted in synergistically enhanced inhibition of tumor growth with less toxicity compared with the NT therapy. Comparing the antitumor activity of NDP plus TXL with that of cisplatin (CDDP) plus TXL or carboplatin (CBDCA) plus TXL, the combination effect of NDP plus TXL was significantly higher than that of CDDP plus TXL or CBDCA plus TXL. These results indicate that the TN therapy may have significant potential in clinical use. |
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Authors:
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H Yamada; N Uchida; R Maekawa; T Yoshioka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 172 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2001-11-01 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 17-25 Citation Subset: IM |
Affiliation:
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Discovery Research Labs, Shionogi Research Laboratories, Shionogi & Co., Ltd, 12-4 Sagisu, 5-chome, Fukusima-ku, Osaka 552-0002, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / administration & dosage* Antineoplastic Agents, Phytogenic / administration & dosage* Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Body Weight / drug effects Carboplatin / administration & dosage Carcinoma, Lewis Lung / drug therapy Cisplatin / administration & dosage Female Liver / drug effects Lung Neoplasms / drug therapy Mice Mice, Inbred C57BL Organoplatinum Compounds / administration & dosage* Paclitaxel / administration & dosage* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antineoplastic Agents, Phytogenic; 0/Organoplatinum Compounds; 15663-27-1/Cisplatin; 33069-62-4/Paclitaxel; 41575-94-4/Carboplatin; 95734-82-0/nedaplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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