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Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system.
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MedLine Citation:
PMID:  3049624     Owner:  NLM     Status:  MEDLINE    
The primary amino acid sequence of contactin, a neuronal cell surface glycoprotein of 130 kD that is isolated in association with components of the cytoskeleton (Ranscht, B., D. J. Moss, and C. Thomas. 1984. J. Cell Biol. 99:1803-1813), was deduced from the nucleotide sequence of cDNA clones and is reported here. The cDNA sequence contains an open reading frame for a 1,071-amino acid transmembrane protein with 962 extracellular and 89 cytoplasmic amino acids. In its extracellular portion, the polypeptide features six type 1 and two type 2 repeats. The six amino-terminal type 1 repeats (I-VI) each consist of 81-99 amino acids and contain two cysteine residues that are in the right context to form globular domains as described for molecules with immunoglobulin structure. Within the proposed globular region, contactin shares 31% identical amino acids with the neural cell adhesion molecule NCAM. The two type 2 repeats (I-II) are each composed of 100 amino acids and lack cysteine residues. They are 20-31% identical to fibronectin type III repeats. Both the structural similarity of contactin to molecules of the immunoglobulin supergene family, in particular the amino acid sequence resemblance to NCAM, and its relationship to fibronectin indicate that contactin could be involved in some aspect of cellular adhesion. This suggestion is further strengthened by its localization in neuropil containing axon fascicles and synapses.
B Ranscht
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of cell biology     Volume:  107     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-04     Completed Date:  1988-11-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1561-73     Citation Subset:  IM    
Massachusetts Institute of Technology, Cambridge 02139.
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MeSH Terms
Amino Acid Sequence
Antigens, Surface / genetics,  physiology*
Base Sequence
Blotting, Northern
Brain / physiology
Cell Adhesion*
Cell Adhesion Molecules
Cell Adhesion Molecules, Neuronal*
Chick Embryo
Cloning, Molecular
DNA / genetics
Fibronectins / genetics
Immunoglobulins / genetics
Immunologic Techniques
Membrane Glycoproteins / genetics,  physiology*
Molecular Sequence Data
Molecular Structure
Multigene Family
Nerve Tissue Proteins / genetics,  physiology*
Neurons / physiology*
Grant Support
Reg. No./Substance:
0/Antigens, Surface; 0/Cell Adhesion Molecules; 0/Cell Adhesion Molecules, Neuronal; 0/Fibronectins; 0/Immunoglobulins; 0/Membrane Glycoproteins; 0/Nerve Tissue Proteins; 0/contactins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 10 Year: 1988
Volume: 107 Issue: 4
First Page: 1561 Last Page: 1573
ID: 2115254
Publisher Id: 89008597
PubMed Id: 3049624

Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system

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