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Sequence of changes in myocardial performance index in relation with aortic isthmus and ductus venosus Doppler in fetuses with early-onset intrauterine growth restriction.
MedLine Citation:
PMID:  21154784     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: To explore the sequence of changes of Myocardial Performance Index (MPI), Aortic Isthmus (AoI) and Ductus Venosus (DV) in fetuses with early-onset intrauterine growth restriction (IUGR). METHODS:: MPI, AoI and DV pulsatility indexes (PI) were performed every 1-7 days in a cohort of IUGR fetuses with abnormal umbilical artery Doppler PI (>95(th) percentile) delivered before 34 weeks. The longitudinal changes were analyzed in the last 30 days before delivery by multilevel and survival analysis. RESULTS:: A total of 430 scans were performed on 115 IUGR fetuses. MPI, AoI PI and DV PI showed linear increases with the progression of fetal deterioration throughout the follow-up study period, but the rate of progression was different. MPI, AoI PI, and DV PI crossed the 95(th) percentile at 26 days, 12 days, and 5 days before delivery, respectively. At the last examination before delivery, the proportion of increased MPI (70.4%) was significantly higher than that of abnormal AoI PI (55.7%; p<0.01) and DV PI (47.8%; p<0.01). CONCLUSION:: In early-onset intrauterine growth restriction, MPI, AoI, and DV Doppler indices increase linearly but with different rates of progression, which provides the basis for further research on their use to improve in utero monitoring and prediction of long term outcome. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Rogelio Cruz-Martinez; Francesc Figueras; Andres Benavides-Serralde; Fatima Crispi; Edgar Hernandez-Andrade; Eduard Gratacos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-10
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Maternal-Fetal Medicine, ICGON, Hospital Clinic-IDIBAPS, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
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