Document Detail

Sequelae of severe respiratory syncytial virus infection in infancy and early childhood among Alaska Native children.
MedLine Citation:
PMID:  12897275     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In 1993-1996, we conducted a nested case-control study to determine risk factors for hospitalization with respiratory syncytial virus (RSV) infection among Alaska Native infants and young children. In the current study, we returned to former RSV case-patients and their control subjects during 1999-2001 to determine whether children who are hospitalized with RSV at <2 years of age are more likely to develop chronic respiratory conditions. METHODS: For each former RSV case-patient and control subject from remote villages in southwest Alaska, we reviewed medical records, interviewed parents, performed physical examinations and spirometry, collected sera, and analyzed chest radiographs. Case-patients were identified through surveillance for RSV hospitalization, and matched control subjects without lower respiratory infection (LRI)-related hospitalization were identified. RESULTS: Hospitalization for RSV infection was associated with a significant increase in wheezing, LRIs, and asthma diagnosis during the first 4 years of life. The association decreased with age and was no longer significant by 5 years of age. However, hospitalization for RSV infection was associated with increased respiratory symptoms and increased chronic productive cough at 5 to 8 years of age. Children who were hospitalized with RSV were not more likely at follow-up to have allergies, eczema, or a positive family history of asthma. CONCLUSIONS: Severe RSV infection in infancy may produce airway injury, which is manifested in chronic productive cough with or without wheezing and recurrent LRIs. Although the association of RSV infection with wheezing seems to be transient, children remain at higher risk for chronic productive cough at 5 to 8 years of age. RSV prevention modalities may prevent sequelae that occur early and later in childhood.
Rosalyn J Singleton; Greg J Redding; Toby C Lewis; Patricia Martinez; Lisa Bulkow; Barbara Morray; Helen Peters; James Gove; Carol Jones; David Stamey; Deborah F Talkington; Jeffrey DeMain; John T Bernert; Jay C Butler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  112     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2003-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  AIM; IM    
Centers for Disease Control and Prevention, National Center for Infectious Diseases, Arctic Investigations Program Anchorage, Anchorage, Alaska 99508, USA.
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MeSH Terms
Age Factors
Asthma / etiology
Case-Control Studies
Child, Preschool
Indians, North American*
Respiratory Sounds / etiology
Respiratory Syncytial Virus Infections / complications*
Respiratory Syncytial Viruses
Respiratory Tract Infections / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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