| Sequelae of maternally derived cytomegalovirus infections in premature infants. | |
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MedLine Citation:
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PMID: 6304275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eighteen of 106 (17%) infants of seropositive mothers, with birth weights less than 1500 gm, acquired cytomegalovirus from a maternal source. Neutropenia, lymphocytosis, thrombocytopenia, and hepatosplenomegaly developed in some infants concomitant with the onset of CMV excretion. Infected infants who excreted CMV at less than 7 weeks of age had longer oxygen requirements than infants who did not excrete CMV until they were older. Passively derived maternal antibody to CMV fell more rapidly over the first few months of life in sick premature infants than would be expected in term infants. Among six infected premature infants, five had undetectable antibody titers when CMV excretion began. Loss of passively acquired antibody and early excretion of virus appear to be associated with symptomatic CMV infections in premature infants of seropositive mothers. |
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Authors:
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A S Yeager; P E Palumbo; N Malachowski; R L Ariagno; D K Stevenson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 102 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1983 Jun |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 918-22 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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analysis Cytomegalovirus / immunology, isolation & purification Cytomegalovirus Infections / etiology*, immunology Female Humans Infant, Newborn Infant, Premature, Diseases / etiology*, immunology Maternal-Fetal Exchange* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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HD 09872/HD/NICHD NIH HHS; RR-81/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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