Document Detail


Sequelae of maternally derived cytomegalovirus infections in premature infants.
MedLine Citation:
PMID:  6304275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eighteen of 106 (17%) infants of seropositive mothers, with birth weights less than 1500 gm, acquired cytomegalovirus from a maternal source. Neutropenia, lymphocytosis, thrombocytopenia, and hepatosplenomegaly developed in some infants concomitant with the onset of CMV excretion. Infected infants who excreted CMV at less than 7 weeks of age had longer oxygen requirements than infants who did not excrete CMV until they were older. Passively derived maternal antibody to CMV fell more rapidly over the first few months of life in sick premature infants than would be expected in term infants. Among six infected premature infants, five had undetectable antibody titers when CMV excretion began. Loss of passively acquired antibody and early excretion of virus appear to be associated with symptomatic CMV infections in premature infants of seropositive mothers.
Authors:
A S Yeager; P E Palumbo; N Malachowski; R L Ariagno; D K Stevenson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  102     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  918-22     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / analysis
Cytomegalovirus / immunology,  isolation & purification
Cytomegalovirus Infections / etiology*,  immunology
Female
Humans
Infant, Newborn
Infant, Premature, Diseases / etiology*,  immunology
Maternal-Fetal Exchange*
Pregnancy
Grant Support
ID/Acronym/Agency:
HD 09872/HD/NICHD NIH HHS; RR-81/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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