| Septo-optic dysplasia with infantile spasms. | |
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MedLine Citation:
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PMID: 3233109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 21-month-old boy with septo-optic dysplasia and infantile spasms is reported. Eighteen hours after birth he had generalized convulsions, dyspnea, and hypoglycemia which were followed by recurrent clonic seizures despite administration of phenobarbital and valproic acid. At 16 months of age he had hypoglycemia and apnea attacks during varicella infection. At 19 months of age left hemiconvulsions and left hemiparesis occurred; his mental and motor development, which had been delayed but progressive, deteriorated. Tonic spasms appeared at 21 months of age and electroencephalography revealed multifocal spikes. At 27 months of age electroencephalography disclosed hypsarrhythmia. Cranial computed tomography depicted brain atrophy, right microphthalmia, and intact septum pellucidum. Magnetic resonance imaging demonstrated hypoplasia of the corpus callosum and a small pituitary gland. Coloboma of the right optic disc was detected. Physical examination revealed short stature, left hemiparesis, micropenis, and cryptorchidism. Endocrinologic loading tests revealed hypofunction of the hypophysial anterior lobe. |
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Authors:
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M Kuriyama; Y Shigematsu; K Konishi; Y Konishi; M Sudo; S Haruki; H Ito |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 4 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1988 Jan-Feb |
Date Detail:
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Created Date: 1989-05-10 Completed Date: 1989-05-10 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 62-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Fukui Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Endocrine Glands
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metabolism Humans Infant, Newborn Male Optic Nerve / abnormalities* Septum Pellucidum / abnormalities* Spasms, Infantile / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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