Document Detail

Septo-optic dysplasia: recognition of causes of false-positive hepatobiliary scintigraphy in neonatal jaundice.
MedLine Citation:
PMID:  3585504     Owner:  NLM     Status:  MEDLINE    
Septo-optic dysplasia (SOD), an unusual clinical syndrome associated with intrahepatic cholestasis, is a cause of false-positive hepatobiliary scintigraphy in patients with neonatal jaundice. Use of the criterion of absence of [99mTc]IDA activity in the gastrointestinal tract by 24 hr, as well as application of the more recently used criterion of normal hepatic extraction, failed to differentiate patients with biliary atresia from those with SOD. Septo-optic dysplasia has clinical and scintigraphic features unique from other causes of conjugated hyperbilirubinemia. Identification of the patients with SOD, in a group of 44 infants being evaluated for neonatal jaundice, improved the overall specificity of hepatobiliary scintigraphy in neonatal jaundice from 65% to 79% and accuracy in identification of patients with biliary atresia from 82% to 90%. Recognition of SOD is important to prevent unnecessary surgical exploration of these patients.
D Kumura; J H Miller; F R Sinatra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  28     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-09     Completed Date:  1987-07-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  966-72     Citation Subset:  IM    
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MeSH Terms
Biliary Atresia / radionuclide imaging*
False Positive Reactions
Imino Acids / diagnostic use
Infant, Newborn
Jaundice, Neonatal / radionuclide imaging*
Optic Nerve / abnormalities*
Organometallic Compounds / diagnostic use
Organotechnetium Compounds*
Septum Pellucidum / abnormalities*
Technetium Tc 99m Disofenin
Reg. No./Substance:
0/Imino Acids; 0/Organometallic Compounds; 0/Organotechnetium Compounds; 0/Technetium Tc 99m Disofenin; 0/technetium Tc 99m PIPIDA

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