| Septo-optic dysplasia and growth hormone deficiency: accelerated pubertal maturation during GH therapy. | |
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MedLine Citation:
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PMID: 1392395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report four patients (three male, one female) with septo-optic dysplasia and growth hormone deficiency. All had GH therapy for a period of four to eight years until reaching final height. In all four cases bone maturation during puberty was accelerated (1.4 to 1.9 "years"/year), resulting in a final height which was clearly below the predicted height. The progress of pubertal stages was very short in all patients. In three patients TSH and prolactin release after TRH stimulation were increased. These data support a hypothalamic original of the endocrine disorder. Insufficient GH release, even after repeated GHRH stimulation, is in contrast to this assumption. In one case there was a late manifestation of neurohormonal diabetes insipidus, which indicates the possibility of later disease progression. MR imaging of the brain demonstrated variable malformation of the septum pellucidum, chiasma and nervus opticus or the pituitary gland, respectively. |
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Authors:
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S Freude; H Frisch; D Wimberger; E Schober; G Hüsler; F Waldhauser; F Aichner |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 81 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 641-5 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University Hospital, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
/
blood,
drug therapy*,
physiopathology Child Child, Preschool Female Growth Growth Disorders / blood, drug therapy*, physiopathology Growth Hormone / deficiency*, therapeutic use Humans Infant Male Optic Nerve / abnormalities* Pituitary Hormones / blood Septum Pellucidum / abnormalities* Syndrome Thyroid Hormones / blood |
| Chemical | |
Reg. No./Substance:
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0/Pituitary Hormones; 0/Thyroid Hormones; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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