Document Detail

Septins as key regulators of actin based processes in bacterial infection.
MedLine Citation:
PMID:  21749282     Owner:  NLM     Status:  MEDLINE    
Many pathogens have evolved a variety of mechanisms to exploit the host-cell actin cytoskeleton during infection, either to enter into cells or to move within cells. These events have been investigated and documented in detail. Yet, a complete picture of the molecules and mechanisms regulating entry and intracellular movement remains to be established. Here we present a series of studies revealing that in addition to actin rearrangements the host cell also employs septins, a relatively newly characterized component of the cell cyto-skeleton, to regulate bacterial entry and restrict the dissemination of cytosolic bacteria. The challenge now is to decipher the precise role of septins during actin rearrangements and how these different cytoskeleton components orchestrate infection processes.
Serge Mostowy; Pascale Cossart
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-07-13
Journal Detail:
Title:  Biological chemistry     Volume:  392     ISSN:  1437-4315     ISO Abbreviation:  Biol. Chem.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-09     Completed Date:  2012-01-26     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9700112     Medline TA:  Biol Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  831-5     Citation Subset:  IM    
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MeSH Terms
Actins / genetics,  metabolism*
Autophagy / genetics,  physiology
Bacterial Infections / genetics,  metabolism
Cytoskeleton / genetics,  metabolism
Listeria / genetics,  metabolism
Septins / genetics,  metabolism*
Grant Support
233348//European Research Council
Reg. No./Substance:
0/Actins; EC 3.6.1.-/Septins

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