Document Detail

Septide but not substance P stimulates inhibitory neurons in guinea-pig ileum.
MedLine Citation:
PMID:  7522175     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that [pGlu6,Pro9]substance P-(6-11) (septide) may act on unusual tachykinin receptors. Here, we investigated the mechanisms of action of septide and other agonists acting on tachykinin NK1 receptors, in the guinea-pig ileum. Responses to septide but not to substance P or [Sar9,Met(O2)11]substance P were significantly (P < 0.01) potentiated by 1 microM tetrodotoxin. The data suggest that septide not only acts directly on smooth muscle tachykinin receptors to produce contraction, but also stimulates another receptor subtype on myenteric neurons to release inhibitory substance(s).
E Burcher; C Stamatakos
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  258     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-19     Completed Date:  1994-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  R9-10     Citation Subset:  IM    
School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.
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MeSH Terms
Guinea Pigs
Ileum / cytology,  drug effects*
Neurons / drug effects*
Peptide Fragments / pharmacology*
Pyrrolidonecarboxylic Acid / analogs & derivatives
Receptors, Neurokinin-1 / drug effects*,  metabolism
Substance P / analogs & derivatives*,  pharmacology*
Reg. No./Substance:
0/Peptide Fragments; 0/Receptors, Neurokinin-1; 110880-55-2/substance P, Sar(9)-Met(O2)(11)-; 33507-63-0/Substance P; 79775-19-2/septide; 98-79-3/Pyrrolidonecarboxylic Acid

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