Document Detail

Septicaemia in the neutropenic patient.
MedLine Citation:
PMID:  4846132     Owner:  NLM     Status:  MEDLINE    
A total of 29 cases of septicaemia proved by blood culture in 22 severely neutropenic patients with acute leukaemia or aplastic anaemia have been studied. The recovery rate was 75% in the Gram-positive septicaemias and 60% in the Gram-negative septicaemias in which treatment response could be evaluated. Neutropenia predisposed to septicaemia and its degree seemed to be important. The underlying state of the bone marrow was an important prognostic factor; the neutrophil count at the time of diagnosis and the infecting organism were less important. Gentamicin was the single most useful antibiotic, and the infection was controlled largely with gentamicin and one other antibiotic, most often carbenicillin. Possibly a similar result could have been obtained with gentamicin alone, but since the bacterial flora in a given environment is changeable empirical antibiotic regimens should remain flexible.
K Atkinson; H E Kay; T J McElwain
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  3     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1974 Jul 
Date Detail:
Created Date:  1974-10-11     Completed Date:  1974-10-11     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  AIM; IM    
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MeSH Terms
Agranulocytosis / complications*
Anemia, Aplastic / complications
Blood Cell Count
Bone Marrow / drug effects,  physiology
Bone Marrow Cells
Carbenicillin / therapeutic use
Child, Preschool
Drug Therapy, Combination
Gentamicins / therapeutic use
Leukemia / complications
Middle Aged
Sepsis / complications*,  drug therapy
Reg. No./Substance:
0/Gentamicins; 4697-36-3/Carbenicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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