Document Detail


Septation and valvar formation in the outflow tract of the embryonic chick heart.
MedLine Citation:
PMID:  11596009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is no agreement, in the chick, about the number of the endocardial cushions within the outflow tract or their pattern of fusion. Also, little is known of their relative contributions to the formation of the arterial valves, the subpulmonary infundibulum, and the arterial valvar sinuses. As the chick heart is an important model for studying septation of the outflow tract, our objective was to clarify these issues. Normal septation of the outflow tract was studied in a series of 60 staged chick hearts, by using stained whole-mount preparations, serial sections, and scanning electron microscopy. A further six hearts were examined subsequent to hatching. At stage 21, two pairs of endocardial cushions were seen within the developing outflow tract. One pair was positioned proximally, with the other pair located distally. By stage 25, a third distal cushion had developed. This finding was before the appearance of two further, intercalated, endocardial cushions, also distally positioned, which were first seen at stage 29. In the arterial segment, the aortic and pulmonary channels were separated by the structure known as the aortopulmonary septum. The dorsal limb of this septum penetrated the distal dorsal cushion, whereas the ventral limb grew between the remaining two distal cushions, both of which were positioned ventrally. The three distal endocardial cushions, and the two intercalated endocardial cushions, contributed to the formation of the leaflets and sinuses of the arterial roots. The two proximal cushions gave rise to a transient septum, which later became transformed into the muscular component of the subpulmonary infundibulum. Concomitant with these changes, an extracardiac tissue plane was formed which separated this newly formed structure from the sinuses of the aortic root. Our study confirms that three endocardial cushions are positioned distally, and two proximally, within the developing outflow tract of the chick. The pattern of the distal cushions, and the position of the ventral limb of the aortopulmonary septum, differs significantly from that seen in mammals.
Authors:
S R Qayyum; S Webb; R H Anderson; F J Verbeek; N A Brown; M K Richardson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Anatomical record     Volume:  264     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-11     Completed Date:  2002-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-83     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Department of Anatomy and Developmental Biology, St. George's Hospital Medical School, London SW17 ORE, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Heart / embryology*
Heart Septum / embryology
Heart Valves / embryology
Models, Anatomic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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