| Septal myectomy results in regression of left ventricular hypertrophy in patients with hypertrophic obstructive cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 15561048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by ventricular hypertrophy that occurs in the absence of predisposing cardiovascular stimuli; approximately one quarter of patients with HCM will have left ventricular (LV) outflow tract obstruction. Transaortic septal myectomy relieves outflow gradients and improves symptoms, but the effect of operation on ventricular hypertrophy is not well defined. METHODS: We reviewed 60 patients who underwent septal myectomy for obstructive HCM; all had complete two-dimensional and Doppler studies including calculation of LV mass and LV mass index before operation and after dismissal. RESULTS: Before myectomy the mean LV outflow gradient was 67 +/- 44 mm Hg, and at dismissal the mean LV outflow gradient was 12 +/- 13 mm Hg (p < 0.004). We found a significant decrease in the LV mass and LV mass index that occurred early after operation and persisted beyond 2 years follow-up. The early decrease in LV mass was greatest in patients younger than 50 years, but patients of all ages benefited from extended septal myectomy with decrease in LV hypertrophy. CONCLUSIONS: Transaortic septal myectomy results in significant decreases in LV mass and LV mass index. This favorable remodeling occurs early after operation and persists beyond 2 years. Whether the regression of LV mass continues to decrease or stabilize over time is unclear. |
| | |
Authors:
|
Subrato J Deb; Hartzell V Schaff; Joseph A Dearani; Rick A Nishimura; Steve R Ommen |
Related Documents
:
|
15491298 - Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous ... 19449958 - Transmural strains in the ovine left ventricular lateral wall during diastolic filling. 12798428 - Aldosterone receptor blockade improves left ventricular remodeling and increases ventri... 15670538 - Comparison of mental stress-induced myocardial ischemia in coronary artery disease pati... 20929978 - Heart failure reversal by ventricular unloading in patients with chronic cardiomyopathy... 9614508 - Preserved frank-starling mechanism in human end stage heart failure. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 78 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2004-11-24 Completed Date: 2005-07-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 2118-22 Citation Subset: AIM; IM |
Affiliation:
|
Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
therapeutic use Adult Aged Calcium Channel Blockers / therapeutic use Cardiomyopathy, Hypertrophic / drug therapy, surgery*, ultrasonography Echocardiography, Doppler Female Follow-Up Studies Heart Septum / surgery* Humans Hypertrophy, Left Ventricular / surgery*, ultrasonography Male Middle Aged Pregnancy Stroke Volume Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Calcium Channel Blockers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term outcome of type B aortic intramural hematoma: comparison with classic aortic dissection tr...
Next Document: Left ventricular assist device performance with long-term circulatory support: lessons from the REMA...