Document Detail

Sepsis-related cardiogenic shock.
MedLine Citation:
PMID:  2209030     Owner:  NLM     Status:  MEDLINE    
To further define cardiovascular abnormalities in patients with septic shock, serial conventional hemodynamic measurements combined with two-dimensional echocardiographic studies were performed at the bedside in 21 patients admitted for an acute episode of sepsis-related circulatory failure. Measurements obtained during the first hours of hospitalization revealed a group of six patients (group 1) with markedly depressed left ventricular function, as evidenced by a low cardiac index (CI) (2.2 +/- 0.8 L/min.m2), reduced left ventricular ejection fraction (LVEF) (21 +/- 8%), and an increased arterial-venous oxygen content difference. Right ventricular systolic function was also severely depressed. These patients were characterized as having sepsis-related cardiogenic shock secondary to profound myocardial depression, which was reversible within 24 to 48 h with inotropic support. The 15 remaining patients (group 2) exhibited an initially increased CI (4.9 +/- 1.8 L/min.m2), with a low systemic vascular resistance. In group 2, LVEF remained within the normal range despite abnormally low peripheral vascular resistance. This finding would suggest the presence of slight to moderate depression of left ventricular systolic function. All patients in this series had a normal left ventricular end-diastolic volume, whether profound myocardial depression was present or not.
F Jardin; D Brun-Ney; B Auvert; A Beauchet; J P Bourdarias
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  18     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-02     Completed Date:  1990-11-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1055-60     Citation Subset:  AIM; IM    
Department of Cardiology, Hôpital Ambroise Paré Boulogne, France.
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MeSH Terms
Cardiac Output
Middle Aged
Pulmonary Wedge Pressure
Sepsis / complications*
Shock, Cardiogenic / etiology,  physiopathology*,  ultrasonography
Stroke Volume
Comment In:
Crit Care Med. 1991 Aug;19(8):1094-5   [PMID:  1860339 ]

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