| Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview. | |
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MedLine Citation:
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PMID: 7583167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple organ dysfunction syndrome (MODS) is the primary cause of death in patients admitted to ICUs. Despite the development of better resuscitation, more powerful antibiotics, and more sophisticated methods for organ support, our ability to rescue patients from established MODS has not improved significantly since the syndrome was first described two decades ago. Rapid advancements in molecular biology have begun to unravel some of the potential mechanisms behind the development of this syndrome, and have suggested many potential therapeutic approaches. To effectively use these new treatment options as they become available, it is necessary to have a clear understanding of how these therapies fit into the current theories on the pathophysiology of MODS. Thus, the goal of this article is to integrate what is new in our understanding of the development of MODS with current concepts regarding potential therapies of this complex and perplexing syndrome. |
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Authors:
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D H Livingston; A C Mosenthal; E A Deitch |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: New horizons (Baltimore, Md.) Volume: 3 ISSN: 1063-7389 ISO Abbreviation: New Horiz Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9416195 Medline TA: New Horiz Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-66 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Intestines / physiopathology Ischemia / physiopathology Macrophages / physiology Microcirculation Multiple Organ Failure / physiopathology* Reperfusion Injury / physiopathology Sepsis / physiopathology* Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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GM 36376/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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