Document Detail

Sepsis and maternal mortality.
MedLine Citation:
PMID:  23385771     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Despite global progress towards reducing maternal mortality, sepsis remains a leading cause of preventable maternal death. This review focuses on current measurement challenges, trends, causes and efforts to curb maternal death from sepsis in high and low-income countries.
RECENT FINDINGS: Under-reporting using routine registration data, compounded by misclassification and unreported deaths, results in significant underestimation of the burden of maternal death from sepsis. In the UK and the Netherlands the recent increase in maternal death from sepsis is mainly attributed to an increase in invasive group A streptococcal infections. Susceptibility to infection may be complicated by modulation of maternal immune response and increasing rates of risk factors such as caesarean section and obesity. Failure to recognize severity of infection is a major universal risk factor. Standardized Surviving Sepsis Campaign (SSC) recommendations for management of severe maternal sepsis are continuing to be implemented worldwide; however, outcomes differ according to models of intensive care resourcing and use.
SUMMARY: The need for robust data with subsequent analyses is apparent. This will significantly increase our understanding of risk factors and their causal pathways, which are critical to informing effective treatment strategies in consideration of resource availability.
Colleen D Acosta; Marian Knight
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  25     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-30     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
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MeSH Terms
Cause of Death
Cesarean Section / adverse effects*
Developed Countries
Developing Countries
Disease Susceptibility
Early Diagnosis
Great Britain / epidemiology
Maternal Mortality / trends
Maternal Welfare
Netherlands / epidemiology
Obesity / complications*
Risk Factors
Sepsis / diagnosis,  etiology*,  mortality*
Streptococcal Infections / diagnosis,  etiology,  mortality*
Streptococcus pyogenes
Survival Rate
Grant Support
RP-PG-0608-10038/PG/OAPP OPHS HHS; RP-PG-0608-10038//Department of Health

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