Document Detail

Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms.
MedLine Citation:
PMID:  20571889     Owner:  NLM     Status:  In-Process    
Cardiac dysfunction is a well-recognized complication of severe sepsis and septic shock. Cardiac dysfunction in sepsis is characterized by ventricular dilatation, reduction in ejection fraction and reduced contractility. Initially, cardiac dysfunction was considered to occur only during the "hypodynamic" phase of shock. But we now know that it occurs very early in sepsis even during the "hyperdynamic" phase of septic shock. Circulating blood-borne factors were suspected to be involved in the evolution of sepsis induced cardiomyopathy, but it is not until recently that the cellular and molecular events are being targeted by researchers in a quest to understand this enigmatic process. Septic cardiomyopathy has been the subject of investigation for nearly half a century now and yet controversies exist in understanding it's pathophysiology. Here, we discuss our understanding of the pathogenesis of septic cardiomyopathy and the complex roles played by nitric oxide, mitochondrial dysfunction, complements and cytokines.
Anthony Flynn; Bhalaghuru Chokkalingam Mani; Paul J Mather
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart failure reviews     Volume:  15     ISSN:  1573-7322     ISO Abbreviation:  Heart Fail Rev     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612481     Medline TA:  Heart Fail Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-11     Citation Subset:  IM    
Cardiology, St. Louis University Hospital, 3635 Vista Ave. 13th Floor, St. Louis, MO 63110, USA.
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