| Sepsis and the heart. | |
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MedLine Citation:
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PMID: 19939836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Septic shock, the most severe complication of sepsis, accounts for approximately 10% of all admissions to intensive care. Our understanding of its complex pathophysiology remains incomplete but clearly involves stimulation of the immune system with subsequent inflammation and microvascular dysfunction. Cardiovascular dysfunction is pronounced and characterized by elements of hypovolaemic, cytotoxic, and distributive shock. In addition, significant myocardial depression is commonly observed. This septic cardiomyopathy is characterized by biventricular impairment of intrinsic myocardial contractility, with a subsequent reduction in left ventricular (LV) ejection fraction and LV stroke work index. This review details the myocardial dysfunction observed in adult septic shock, and discusses the underlying pathophysiology. The utility of using the regulatory protein troponin for the detection of myocardial dysfunction is also considered. Finally, options for the management of sepsis-induced LV hypokinesia are discussed, including the use of levosimendan. |
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Authors:
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J D Hunter; M Doddi |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: British journal of anaesthesia Volume: 104 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 3-11 Citation Subset: IM |
Affiliation:
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Macclesfield District General Hospital, Victoria Road, Macclesfield SK10 3BL, UK. jdhunter@talk21.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Humans Prognosis Shock, Septic / complications*, physiopathology Troponin / blood Ventricular Dysfunction / diagnosis, etiology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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