Document Detail


Sepsis, complement and the dysregulated inflammatory response.
MedLine Citation:
PMID:  19725914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sepsis in human beings is a major problem involving many individuals and with a high death rate. Except for a single drug (recombinant activated protein C) that has been approved for treatment of septic patients, supportive measures represent the main clinical approach. There are many models of experimental sepsis, mostly in rodents. A commonly used model is cecal ligation and puncture (CLP). In this model, robust activation of complement occurs together with up-regulation of C5a receptors (C5aR, C5L2) in a variety of different organs (lungs, kidneys, liver, heart). In septic human beings there is abundant evidence for complement activation. Interception of C5a or its receptors in the CLP model greatly improves survival in septic rodents. There is compelling evidence that CLP causes an intense pro-inflammatory state and that C5a interaction with its receptors can be linked to apoptosis of the lymphoid system and cells of the adrenal medulla, loss of innate immune functions of blood neutrophils, consumptive coagulopathy and cardiac dysfunction. These findings may have implications for therapeutic interventions in human beings with sepsis.
Authors:
Peter A Ward; Hongwei Gao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-09-01
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  13     ISSN:  1582-4934     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-10-28     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  4154-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Complement System Proteins / immunology*
Humans
Inflammation / complications*,  immunology*
Models, Immunological
Sepsis / complications*,  immunology*
Signal Transduction / immunology
Grant Support
ID/Acronym/Agency:
GM-029507/GM/NIGMS NIH HHS; GM-61656/GM/NIGMS NIH HHS; HL-092905/HL/NHLBI NIH HHS; R01 GM029507/GM/NIGMS NIH HHS; R01 GM029507-29/GM/NIGMS NIH HHS; R01 GM061656/GM/NIGMS NIH HHS; R01 GM061656-10/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9007-36-7/Complement System Proteins
Comments/Corrections

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