Document Detail

Sepsis, coagulation and anticoagulants.
MedLine Citation:
PMID:  20509839     Owner:  NLM     Status:  MEDLINE    
Sepsis is one of the major health problems all over the word. Its pathophysiological mechanisms are not completely understood, but coagulation alterations are a hallmark of this syndrome. There is a clear exacerbation of coagulation and a suppression of control mechanisms of this process, including a reduction in fibrinolysis with consequent impairment of fibrin removal. The leading cause of these alterations is the proinflammatory state of those patients, characterized by high cytokine levels, increase in adhesion molecules expression, endothelial and platelets activation, release of microparticles and other related phenomena. Moreover, coagulation and inflammation are linked in a variety of pathways with mutual activation that ultimately contributes for its maintenance. The components of this process will be herein discussed as well as therapeutical alternatives that have excessive coagulation as a target.
Flavia Ribeiro Machado; Murillo Santucci Cesar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrine, metabolic & immune disorders drug targets     Volume:  10     ISSN:  2212-3873     ISO Abbreviation:  Endocr Metab Immune Disord Drug Targets     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-23     Completed Date:  2011-01-04     Revised Date:  2012-04-19    
Medline Journal Info:
Nlm Unique ID:  101269157     Medline TA:  Endocr Metab Immune Disord Drug Targets     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  204-13     Citation Subset:  IM    
Department of Anesthesiology, Pain and Critical Care - Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
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MeSH Terms
Anticoagulants / blood*,  immunology
Blood Coagulation / immunology*
Blood Platelets / immunology*
Disseminated Intravascular Coagulation / blood*,  immunology,  therapy
Inflammation Mediators / blood
Sepsis / blood*,  complications,  immunology
Reg. No./Substance:
0/Anticoagulants; 0/Inflammation Mediators

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