Document Detail


Separation of retinoid-induced epidermal and dermal thickening from skin irritation.
MedLine Citation:
PMID:  14564458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of the synthetic retinoid MDI-301, in which the carboxylic acid of 9- cis-retinoic acid (9-cis-RA) is replaced with an ester linkage, to induce epidermal and dermal thickening and skin irritation (erythema and flaking) in hairless (rhino) mice following its topical application was investigated in comparison with that of 14-all- trans-retinoic acid (14-all-trans-RA) and 9-cis-RA. MDI-301 induced epidermal proliferation leading to a thickened epidermis. Treated animals also demonstrated a prominent band of organized connective tissue immediately below the epidermis. In its ability to induce epidermal thickening, MDI-301 was quantitatively similar to 14-all-trans-RA and 9-cis-RA. However, unlike 14-all-trans-RA and 9-cis-RA, which produced skin irritation associated with a perivascular influx of mononuclear leukocytes into the dermis, there was no evidence of irritation with MDI-301 and little leukocyte infiltration. Intraperitoneal injection of either 14-all-trans-RA or MDI-301 also resulted in epidermal and dermal thickening. Irritation of skin was not observed in these animals but splenomegaly was prominent in animals treated with either agent.
Authors:
James Varani; Helene Fligiel; Jian Zhang; Muhammad Nadeem Aslam; Yi Lu; Lindsay A Dehne; Evan T Keller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-10-16
Journal Detail:
Title:  Archives of dermatological research     Volume:  295     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-08-12     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  255-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Dermatitis, Irritant / pathology*
Dermis / pathology*
Epidermis / pathology*
Fibroblasts / cytology,  drug effects
Humans
Keratinocytes / cytology,  drug effects
Mice
Mice, Hairless
Retinoids / chemistry,  pharmacology*
Tretinoin / analogs & derivatives*,  chemistry,  pharmacology
Grant Support
ID/Acronym/Agency:
AR 49621/AR/NIAMS NIH HHS; DK 59169/DK/NIDDK NIH HHS; R01 DK059169/DK/NIDDK NIH HHS; R01 DK059169-03/DK/NIDDK NIH HHS; R44 AR049621-03/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/MDI 301; 0/Retinoids; 5300-03-8/alitretinoin; 5688UTC01R/Tretinoin
Comments/Corrections

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