| Separation, purification, and α-glucosidase inhibition of polysaccharides from Coriolus versicolor LH1 mycelia. | |
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MedLine Citation:
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PMID: 23218298 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Intracellular polysaccharides (iPs) were separated and purified from Coriolus versicolor LH1 mycelia and characterized for their α-glucosidase inhibitory properties. Three iP fractions (iPL-F5-2-1, iPL-F5-4-1, and iPL-F5-5-1) were extracted, separated, and purified from LH1 mycelia using microwave extraction technology, a DEAE-Sepharose™ CL-6B column, a Diaion(®) HP20 macroporous adsorption column, and a Sephadex™ G-50 gel-permeation column. The principal constituents of iPL-F5-2-1, iPL-F5-4-1, and iPL-F5-5-1 were saponins and polyphenoic compound mixtures. The enzyme inhibition activity, IC(50) values, of these three fractions were 1.7, 1.8, and 0.8mg/mL, respectively. The α-glucosidase inhibitory properties were related to the presence of α-(1,4) glycosidic linkages in the polysaccharide structure and the total relative percentage of d-glucose and d-galactose in the structure of polysaccharides, other than triterpenoids. |
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Authors:
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Wen-Kuang Hsu; Tai-Hao Hsu; Fang-Yi Lin; Yuan-Kai Cheng; John Po-Wen Yang |
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Publication Detail:
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Type: Journal Article Date: 2012-10-08 |
Journal Detail:
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Title: Carbohydrate polymers Volume: 92 ISSN: 1879-1344 ISO Abbreviation: Carbohydr Polym Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307156 Medline TA: Carbohydr Polym Country: England |
Other Details:
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Languages: eng Pagination: 297-306 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Natural Products Chemistry Research Laboratory, Department of Bioindustry Technology, Dayeh University, Changhua 51591, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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