| Separation of complex mixtures of fluorobenzoic acids by capillary electrophoresis. | |
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MedLine Citation:
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PMID: 19142912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluorobenzoic acids are important intermediates in the synthesis of antibacterial drugs. Conditions for the separation of mixtures of twenty-five acids by CE have been optimized. A set of conditions with phosphate buffer (pH 3.1), successive multiple ionic-polymer layer (SMIL) coating capillary, and negative separation voltage provided a short time separation based on the difference in the acidic dissociation constant (pK(a)) of the sample acids. Addition of ACN to the separation solution improved the selectivity resulting in a broader distribution of migration times of the samples. The addition of tetradecyltrimethylammonium chloride below the CMC was also effective in changing the migration pattern of fluorobenzoic acids. Furthermore, practical utility was demonstrated through quantitative studies on the optimized condition including the durability of the SMIL coating. |
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Authors:
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Tsuguhide Isemura; Fumihiko Kitagawa; Koji Otsuka |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of separation science Volume: 32 ISSN: 1615-9314 ISO Abbreviation: J Sep Sci Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088554 Medline TA: J Sep Sci Country: Germany |
Other Details:
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Languages: eng Pagination: 381-7 Citation Subset: IM |
Affiliation:
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Analytical Science & TechnologyFunction, Asahi Glass Co., Ltd.Research Center, Yokohama,Kanagawa, Japan. tsuguhide-isemura@agc.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Benzoic Acids
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chemistry,
isolation & purification* Chromatography, High Pressure Liquid Cyclodextrins / chemistry Electrophoresis, Capillary / methods* Fluorine Compounds / chemistry, isolation & purification* Hydrogen-Ion Concentration Molecular Structure Silicon Dioxide / chemistry Surface-Active Agents / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Benzoic Acids; 0/Cyclodextrins; 0/Fluorine Compounds; 0/Surface-Active Agents; 7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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