Document Detail

Separation anxiety at the centromere.
MedLine Citation:
PMID:  10932097     Owner:  NLM     Status:  MEDLINE    
During mitosis, replicated sister-chromatids must maintain cohesion as they attach to the mitotic spindle. At anaphase, cohesion is lost simultaneously along the entire chromosome, releasing sisters from one another and allowing them to segregate to opposite poles. During meiosis, sisters separate in a two-step process. At anaphase of meiosis I, cohesion is lost along the chromosome arms but is maintained at centromeric regions. Not until meiosis II are sister chromatids able to break the connection at the centromere and separate away from one another. Recent studies suggest that the centromere exhibits dynamics that are very different compared with those of the chromatid arms during both mitosis and meiosis. This review discusses the nature of the specialized chromatid cohesion seen at the centromere.
K J Dej; T L Orr-Weaver
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  10     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-11     Completed Date:  2000-10-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  392-9     Citation Subset:  IM    
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
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MeSH Terms
Anaphase / physiology*
Centromere / physiology*
Chromatids / physiology*
Meiosis / physiology*
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