Document Detail

Separate assessment of forearm cortical and trabecular bone density from standard densitometry data.
MedLine Citation:
PMID:  11680799     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cortical and trabecular bone are different bone components. Their mineral density cannot be measured directly by areal bone densitometry. AIM: To introduce a method for assessment of pure radial cortical and trabecular bone density based on standard densitometry data. METHOD: The study included 418 healthy females (aged 20-83 years, body mass index between 19 and 30) free of previous fractures and conditions or drugs affecting bone metabolism; as well as a group of 64 age-matched females with early menopause. Forearm bone density was measured by single X-ray absorptiometry and calculated separately for cortical and trabecular bone. Age-adjusted bone density curves were built. RESULTS: Peak bone density was found to occur between 30 and 34 years of age and was 0.561 g/cm2 for cortical and 0.281 g/cm2 for trabecular bone. In comparison, lowest values were registered between 70 and 74 years of age; cortical bone density reduced by 26% and trabecular density by 44%. Both bone density profiles through life reflected the earlier peri- and postmenopausal (mainly trabecular) and later senile (cortical bone also involved) changes in bone mass. A step-wise pattern of trabecular bone reduction was registered with acceleration around 45, 55 and 65 years. The effects of early menopause on trabecular and cortical bone were tested in the prematurely menopausal women. CONCLUSIONS: The ability of our model to discriminate between natural and premature menopause was moderate. Although hypothetical (based on calculations from integral densitometry data rather than on direct measurements), our method could differentiate between cortical and trabecular osteopenia and may prove helpful in assessing the type of osteoporosis, in making therapy choices and monitoring response to therapy based on forearm bone density.
M A Boyanov; P R Popivanov; C Roux
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of medicine     Volume:  33     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-26     Completed Date:  2002-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  497-506     Citation Subset:  IM    
Endocrinology Clinic, Medical University of Sofia, Alexandrov's Hospital, Sofia, Bulgaria.
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MeSH Terms
Age Factors
Aged, 80 and over
Bone Density / physiology*
Bone and Bones / physiopathology*,  radiography*
Middle Aged
Osteoporosis, Postmenopausal / diagnosis*,  epidemiology
Reference Values
Risk Factors
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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