Document Detail


Separable substrates for anticipatory and consummatory food chemosensation.
MedLine Citation:
PMID:  18341997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perception of the smell of a food precedes its ingestion and perception of its flavor. The neurobiological underpinnings of this association are not well understood. Of central interest is whether the same neural circuits code for anticipatory and consummatory phases. Here, we show that the amygdala and mediodorsal thalamus respond preferentially to food odors that predict immediate arrival of their associated drink (FO+) compared to food odors that predict delivery of a tasteless solution (FO-) and compared to the receipt of the drink. In contrast, the left insula/operculum responds preferentially to the drink, whereas the right insula/operculum and left orbitofrontal cortex respond to FO+ and drink. These findings indicate separable and overlapping representation of anticipatory and consummatory chemosensation. Moreover, since ratings of perceived pleasantness of FO+, FO-, and drink were similar, the response in the amygdala and thalamus cannot reflect acquired affective value but rather predictive meaning or biological relevance.
Authors:
Dana M Small; Maria G Veldhuizen; Jennifer Felsted; Y Erica Mak; Francis McGlone
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuron     Volume:  57     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-08     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  786-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping / methods
Chemoreceptor Cells / physiology
Feeding Behavior / physiology*,  psychology
Female
Food*
Humans
Male
Nerve Net / physiology
Olfactory Pathways / physiology
Smell / physiology
Stimulation, Chemical
Taste / physiology
Grant Support
ID/Acronym/Agency:
R03 DA022292/DA/NIDA NIH HHS; R03 DA022292-01/DA/NIDA NIH HHS; R03 RDA022292A//PHS HHS
Comments/Corrections

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