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Sentinel lymph node biopsy for squamous cell carcinoma of the extremities: case report and review of the literature.
MedLine Citation:
PMID:  21508400     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Lymph node metastases from squamous cell carcinoma (SCC) can reach 20% in some high risk subgroups, and while early detection of metastasis may potentially improve overall and/or disease-specific survival, techniques for early detection have not been established. One such technique is the use of sentinel lymph node biopsy (SLNB), however its role for SCC of the extremities has not been explored.
MATERIALS AND METHODS: A case that highlights the utility of SLNB in this setting is described, and a systematic review of the literature was undertaken in order to establish the current evidence for its use.
RESULTS: There have been no prospective clinical trials performed to investigate the role of SLNB in this setting. Thirty-two cases utilizing SLNB for peripheral SCCs have been reported, with a 28.1% rate of positive SLN, and low false-positive and false-negative rates. No complications were reported.
CONCLUSION: SLNB for SCC of the limbs has been scarcely reported, but those cases reported do collectively demonstrate a high positive predictive value for lymph node metastasis and a low false-positive rate, with poor prognostic variables identified. The efficacy of SLNB in this setting requires further investigation.
Authors:
Yang Yang Liu; Warren M Rozen; Richard Rahdon
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  31     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1443-6     Citation Subset:  IM    
Affiliation:
MBBS BMedSc PGDipSurgAnat, Department of Plastic and Reconstructive Surgery, Geelong Hospital, Bellerine St, Victoria, Australia, 3220. warrenrozen@hotmail.com.
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