| Sentinel lymph node excision and PET-CT in the initial stage of malignant melanoma: a retrospective analysis of 61 patients with malignant melanoma in American Joint Committee on Cancer stages I and II. | |
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MedLine Citation:
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PMID: 20187901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Sentinel lymph node excision (SLNE) for the detection of regional nodal metastases and staging of malignant melanoma has resulted in some controversies in international discussions. Positron emission tomography with computerized tomography (PET-CT), a noninvasive imaging procedure for the detection of regional nodal metastases, has increasingly become of interest. Our study is a direct comparison of SLNE and PET-CT in patients with early-stage malignant melanoma. MATERIALS AND METHODS: We retrospectively analyzed data from 61 patients with primary malignant melanoma with a Breslow index greater than 1.0 mm. RESULTS: Metastatic SLNs were found in 14 patients (23%); 17 metastatic lymph nodes were detected overall, only one of which was identified preoperatively using PET-CT. Thus, PET-CT showed a sensitivity of 5.9% and a negative predictive value of 78%. CONCLUSION: SLNE is much more sensitive than PET-CT in discovering small lymph node metastases. We consider PET-CT unsuitable for the evaluation of early regional lymphatic tumor dissemination in this patient population and recommend that it be limited to malignant melanomas of American Joint Committee on Cancer stages III and IV. We therefore recommend the routine use of SLNE for tumor staging and stratification for adjuvant therapy of patients with stage I and II malignant melanoma. |
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Authors:
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Joachim Klode; Joachim Dissemond; Stephan Grabbe; Uwe Hillen; Thorsten Poeppel; Carsten Boeing |
Publication Detail:
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Type: Journal Article Date: 2010-02-19 |
Journal Detail:
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Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 36 ISSN: 1524-4725 ISO Abbreviation: Dermatol Surg Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-05-10 Revised Date: 2010-12-17 |
Medline Journal Info:
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Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: United States |
Other Details:
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Languages: eng Pagination: 439-45 Citation Subset: IM |
Affiliation:
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Dermatology, Venereology, and Allergology, University School of Medicine Essen-Duisburg, Hufelandstr. 55, 45122 Essen, Germany. joachim.klode@uk-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Fluorodeoxyglucose F18 Humans Lymph Node Excision Lymph Nodes / pathology*, radiography, radionuclide imaging*, surgery Lymphatic Metastasis Male Melanoma / diagnosis*, pathology, secondary*, surgery Middle Aged Neoplasm Staging Positron-Emission Tomography Retrospective Studies Sentinel Lymph Node Biopsy / methods* Skin Neoplasms / diagnosis*, pathology*, surgery Surgery, Computer-Assisted / methods* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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Dermatol Surg. 2010 Dec;36(12):2082-3
[PMID:
21126282
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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