Document Detail

Sensory stimulation (acupuncture) increases the release of calcitonin gene-related peptide in the saliva of xerostomia sufferers.
MedLine Citation:
PMID:  10657499     Owner:  NLM     Status:  MEDLINE    
Over the last decade, several patients afflicted with xerostomia have been treated with acupuncture. Their salivary flow rates increased significantly and the improvement lasted during a long observation period. We also found that the release of several neuropeptides in the saliva of healthy subjects can be increased by acupuncture stimulation. The concentration of vasoactive intestinal polypeptide increased significantly in the saliva of xerostomic patients after acupuncture treatment. The release of the neuropeptide calcitonin gene-related peptide (CGRP) was investigated in the saliva of xerostomic patients in order to elucidate further the mechanisms of the effect of sensory stimulation (acupuncture) on the salivary secretion. CGRP-like immunoreactivity was measured with radioimmunoassay (RIA) before and after a double series of acupuncture treatment, in stimulated saliva of 14 patients who suffered from xerostomia. The results showed that the concentration of CGRP increased significantly (P<0.001) in the saliva of these patients after the end of acupuncture treatment as compared to base-line levels. Taking into consideration the influence of CGRP on the salivary flow, as well as its trophic effect, we concluded that the increased release of CGRP could be one of the factors that affect positively the salivary flow rates of xerostomic patients who were treated with acupuncture.
I Dawidson; B Angmar-Mânsson; M Blom; E Theodorsson; T Lundeberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropeptides     Volume:  33     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Harcourt Publishers Ltd.
Department of Cariology, Karolinska Institutet, Box 4064, Huddinge, 141 04, Sweden.
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MeSH Terms
Acupuncture Therapy*
Calcitonin Gene-Related Peptide / analysis,  metabolism*
Chromatography, High Pressure Liquid
Middle Aged
Neurons, Afferent / physiology
Physical Stimulation
Saliva / metabolism*
Xerostomia / metabolism*,  therapy*
Reg. No./Substance:
83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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