Document Detail


Sensory signalling effects of tegaserod in patients with irritable bowel syndrome with constipation.
MedLine Citation:
PMID:  18004988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tegaserod relieves overall and multiple individual constipation-predominant irritable bowel syndrome (IBS-C) symptoms. However, mechanisms for the relief of abdominal pain/discomfort are not well understood. The effects of tegaserod on rectal sensitivity to distension were measured by the nociceptive flexion RIII reflex, as evidenced by spinal hyperexcitability (i.e. increase or facilitation of the RIII reflex), in IBS-C patients. A randomized, double-blind, placebo-controlled, parallel study was performed in 30 women with IBS-C. The effects of slow ramp rectal distension on the RIII reflex, recorded from the lower limb, were measured before [first experimental day (D1)] and after 7 days [day 8 (D8)] of placebo (n=15) or 6 mg tegaserod bid (n=15). Pressure-volume and sensation-volume relationships were measured during distension, and patients reported their IBS symptoms daily. On D1, rectal distension facilitated the RIII reflex in both treatment groups. On D8 vs D1 these facilitatory effects were significantly lower (P<0.001, analysis of variance) after tegaserod (mean reduction: -30.3+/-11.9%) than placebo (mean reduction: -10.1+/-12.9%). No significant changes in the volume-sensation relationship or differences in compliance were observed with tegaserod or placebo. In conclusion, tegaserod reduces the facilitatory effects of rectal distension on the RIII reflex in women with IBS-C.
Authors:
J-M Sabaté; D Bouhassira; C Poupardin; A Wagner; Y Loria; B Coffin
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-11-14
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  20     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-17     Completed Date:  2008-05-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-41     Citation Subset:  IM    
Affiliation:
AP-HP, Hôpital Louis Mourier, Service d'Hépato-Gastroentérologie, Colombes, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Compliance
Constipation / etiology,  physiopathology*
Double-Blind Method
Female
Humans
Indoles / pharmacology*
Irritable Bowel Syndrome / complications,  physiopathology*
Manometry
Middle Aged
Placebos
Rectum / drug effects*,  physiopathology
Reflex / drug effects*
Serotonin Agonists / pharmacology*
Chemical
Reg. No./Substance:
0/Indoles; 0/Placebos; 0/Serotonin Agonists; 145158-71-0/tegaserod
Comments/Corrections

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