| Sensory responsiveness of brain noradrenergic neurons is modulated by endogenous brain serotonin. | |
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MedLine Citation:
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PMID: 8221096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous results have indicated that application of serotonin (5-HT) onto noradrenergic locus coeruleus (LC) neurons selectively attenuates the response of these cells to excitatory amino acids (EAAs). Other studies revealed that certain sensory responses of LC neurons are mediated by EAA inputs. We examined the role of endogenous 5-HT in modulating sensory responses of LC neurons that are EAA-mediated. LC neurons recorded in rats pretreated with the serotonin (5-HT) depletor, p-chlorophenylalanine (PCPA), exhibited increased responsiveness to electrical stimulation of a rear footpad. Conversely, injection of the 5-HT precursor, 5-hydroxytryptophan (5-HTP), reversed this effect of PCPA and attenuated this sensory response of LC neurons in drug-naive animals. Neither treatment altered the spontaneous discharge rate of LC neurons. These results are consistent with previous findings indicating that 5-HT has potent but selective effects on EAA-mediated responses of LC neurons, and in addition point to a possible functional role for endogenous 5-HT in controlling sensory-evoked LC activity. |
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Authors:
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R Shiekhattar; G Aston-Jones |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 623 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-12-21 Completed Date: 1993-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 72-6 Citation Subset: IM |
Affiliation:
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Department of Mental Health Sciences, Hahnemann University, Philadelphia, PA 19102. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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5-Hydroxytryptophan
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pharmacology Animals Brain / physiology* Electric Stimulation Evoked Potentials / drug effects Fenclonine / pharmacology Hindlimb / innervation Male Neurons / drug effects, physiology* Neurons, Afferent / drug effects, physiology* Rats Rats, Sprague-Dawley Sciatic Nerve / physiology* Serotonin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DA 06214/DA/NIDA NIH HHS; NS 24698/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 56-69-9/5-Hydroxytryptophan; 7424-00-2/Fenclonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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