Document Detail

Sensory neuropathic cough: a common and treatable cause of chronic cough.
MedLine Citation:
PMID:  16815176     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe our experience with chronic sensory neuropathic cough and its response to amitriptyline in a first group of patients.
STUDY DESIGN AND SETTING: A prospective cohort of patients is described in detail. Each was referred to an academic laryngological practice after extensive prior negative workup for cough and failure to respond to various treatments. Each of these patients was treated with amitriptyline and asked to report the effect on the cough at fixed intervals by means of telephone interviews.
RESULTS: A first cohort of 12 consecutive patients with a chronic, nonproductive cough that lasted between 2 months and 20 years, with no (formerly) discernible cause is described. Purely clinical criteria of inclusion and exclusion are proposed. All patients had at least 40% reduction of self-reported symptoms, with most describing between 75% to 100% short-term relief.
CONCLUSION: Sensory neuropathic cough can be diagnosed clinically in patients with chronic idiopathic cough. A trial of amitriptyline 10 mg or of other anti-neuralgia type medications may be helpful. Longer term and controlled trials are warranted to validate this entity and prove efficacy of neurologic medication in chronic sensory neuropathic cough.
Robert W Bastian; Abhay M Vaidya; Kathelijne G Delsupehe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  135     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-03     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
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MeSH Terms
Adrenergic Uptake Inhibitors / therapeutic use
Amitriptyline / therapeutic use
Bronchial Provocation Tests
Chronic Disease
Cough / diagnosis,  drug therapy,  etiology*
Diagnosis, Differential
Follow-Up Studies
Middle Aged
Peripheral Nervous System Diseases / complications*,  drug therapy
Prospective Studies
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 1806D8D52K/Amitriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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