| Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. | |
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MedLine Citation:
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PMID: 12086669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nerves and blood vessels are branched structures, but whether their branching patterns are established independently or coordinately is not clear. Here we show that arteries, but not veins, are specifically aligned with peripheral nerves in embryonic mouse limb skin. Mutations that eliminate peripheral sensory nerves or Schwann cells prevent proper arteriogenesis, while those that disorganize the nerves maintain the alignment of arteries with misrouted axons. In vitro, sensory neurons or Schwann cells can induce arterial marker expression in isolated embryonic endothelial cells, and VEGF(164/120) is necessary and sufficient to mediate this induction. These data suggest that peripheral nerves provide a template that determines the organotypic pattern of blood vessel branching and arterial differentiation in the skin, via local secretion of VEGF. |
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Authors:
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Yoh-suke Mukouyama; Donghun Shin; Stefan Britsch; Masahiko Taniguchi; David J Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 109 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-27 Completed Date: 2002-07-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 693-705 Citation Subset: IM |
Affiliation:
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Division of Biology 216-76, California Institute of Technology, 1201 E. California Boulevard, Pasadena 91125, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / cytology*, embryology, metabolism Cell Differentiation Cell Movement Endothelial Growth Factors / metabolism, physiology Extremities / embryology Immunohistochemistry In Situ Hybridization Lymphokines / metabolism, physiology Mice Microscopy, Fluorescence Muscle, Smooth / cytology Mutation Neurons / metabolism Neurons, Afferent / metabolism*, physiology* Receptor, erbB-3 / metabolism Reverse Transcriptase Polymerase Chain Reaction Schwann Cells / metabolism Skin / embryology Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL66221/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC 2.7.10.1/Receptor, erbB-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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