Document Detail

Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
MedLine Citation:
PMID:  12086669     Owner:  NLM     Status:  MEDLINE    
Nerves and blood vessels are branched structures, but whether their branching patterns are established independently or coordinately is not clear. Here we show that arteries, but not veins, are specifically aligned with peripheral nerves in embryonic mouse limb skin. Mutations that eliminate peripheral sensory nerves or Schwann cells prevent proper arteriogenesis, while those that disorganize the nerves maintain the alignment of arteries with misrouted axons. In vitro, sensory neurons or Schwann cells can induce arterial marker expression in isolated embryonic endothelial cells, and VEGF(164/120) is necessary and sufficient to mediate this induction. These data suggest that peripheral nerves provide a template that determines the organotypic pattern of blood vessel branching and arterial differentiation in the skin, via local secretion of VEGF.
Yoh-suke Mukouyama; Donghun Shin; Stefan Britsch; Masahiko Taniguchi; David J Anderson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  109     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-07-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-705     Citation Subset:  IM    
Division of Biology 216-76, California Institute of Technology, 1201 E. California Boulevard, Pasadena 91125, USA.
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MeSH Terms
Arteries / cytology*,  embryology,  metabolism
Cell Differentiation
Cell Movement
Endothelial Growth Factors / metabolism,  physiology
Extremities / embryology
In Situ Hybridization
Lymphokines / metabolism,  physiology
Microscopy, Fluorescence
Muscle, Smooth / cytology
Neurons / metabolism
Neurons, Afferent / metabolism*,  physiology*
Receptor, erbB-3 / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Schwann Cells / metabolism
Skin / embryology
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Grant Support
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC, erbB-3

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