Document Detail


Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin.
MedLine Citation:
PMID:  12086669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nerves and blood vessels are branched structures, but whether their branching patterns are established independently or coordinately is not clear. Here we show that arteries, but not veins, are specifically aligned with peripheral nerves in embryonic mouse limb skin. Mutations that eliminate peripheral sensory nerves or Schwann cells prevent proper arteriogenesis, while those that disorganize the nerves maintain the alignment of arteries with misrouted axons. In vitro, sensory neurons or Schwann cells can induce arterial marker expression in isolated embryonic endothelial cells, and VEGF(164/120) is necessary and sufficient to mediate this induction. These data suggest that peripheral nerves provide a template that determines the organotypic pattern of blood vessel branching and arterial differentiation in the skin, via local secretion of VEGF.
Authors:
Yoh-suke Mukouyama; Donghun Shin; Stefan Britsch; Masahiko Taniguchi; David J Anderson
Related Documents :
18446629 - Peripheral vascular disease: who gets it and why? a histomorphological analysis of 261 ...
16625229 - Doppler evaluation of erectile dysfunction - part 2.
12799729 - Relationship of peripheral arterial compliance and standard cardiovascular risk factors.
910809 - Medial calcinosis of mönckeberg. a review of the problem and a description of a patien...
18074909 - Occurrence of peripheral arterial disease in a belgian cohort of patients with cardiova...
9282279 - Relationship between splanchnic, peripheral and cardiac haemodynamics in liver cirrhosi...
24265569 - Endovascular treatment of aneurysm of splenic artery arising from splenomesentric trunk...
11058709 - Apolipoprotein e polymorphism and carotid artery intima-media thickness in a random sam...
21737559 - Pulmonary fibrosis is associated with an elevated risk of thromboembolic disease.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  109     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-07-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-705     Citation Subset:  IM    
Affiliation:
Division of Biology 216-76, California Institute of Technology, 1201 E. California Boulevard, Pasadena 91125, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / cytology*,  embryology,  metabolism
Cell Differentiation
Cell Movement
Endothelial Growth Factors / metabolism,  physiology
Extremities / embryology
Immunohistochemistry
In Situ Hybridization
Lymphokines / metabolism,  physiology
Mice
Microscopy, Fluorescence
Muscle, Smooth / cytology
Mutation
Neurons / metabolism
Neurons, Afferent / metabolism*,  physiology*
Receptor, erbB-3 / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Schwann Cells / metabolism
Skin / embryology
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Grant Support
ID/Acronym/Agency:
HL66221/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC 2.7.10.1/Receptor, erbB-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adaptive filtering of vibrissa input in motor cortex of rat.
Next Document:  Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell...