Document Detail


Sensory information processing may be neuroenergetically more demanding in migraine patients.
MedLine Citation:
PMID:  23381352     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Electrophysiological studies of stimulus-evoked brain activation suggest that sensory processing in migraine patients is abnormal between attacks. The main findings are increased amplitudes and decreased habituation of cortical evoked potentials. Recent findings in healthy individuals showed that evoked potentials result mainly from phase resetting of background electroencephalographic activity. We recorded single trial visual evoked potentials during repetitive visual stimulation in migraine patients and healthy controls and analyzed these in the frequency domain for amplitude and phase. Increases in visual evoked potential amplitudes in migraine patients are explained almost entirely by increases in local amplitude, rather than increases in phase synchrony across trials. As amplitude modulation is generally considered more energy demanding than phase synchronization, this may explain the increased vulnerability of migraine patients to sensory stressors and the effectiveness of drugs that reduce evoked potential amplitudes or enhance aerobic energy metabolism.
Authors:
Andreas R Gantenbein; Peter S Sandor; Juan Fritschy; Robert Turner; Peter J Goadsby; Holger Kaube
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  24     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  202-5     Citation Subset:  IM    
Affiliation:
aRehaClinic, Cantonal Hospital Baden, Bad Zurzach bHeadache and Pain Unit, Department of Neurology, University Hospital Zurich cUniversity of Zurich, Zurich, Switzerland dDepartment of Medical Physics & Bioengineering, University College London, London, UK eMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig fNeurology and Headache Centre, Münchner Freiheit, Munich, Germany gDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
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