Document Detail

Sensory hyperreactivity--a possible mechanism underlying cough and asthma-like symptoms.
MedLine Citation:
PMID:  9930599     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Investigations of patients referred for suspected asthma have revealed a little-known group with symptoms suggesting hyperreactive airways in whom provocation with methacholine does not lead to bronchial obstruction. The underlying mechanisms are not known, and no objective diagnostic method has been available. METHODS: Provocations by inhalation of capsaicin solutions in stepwise increasing concentrations were used. Ten patients with asthma-like symptoms after exposure to nonspecific irritating stimuli, but without IgE-mediated allergy or demonstrable bronchial obstruction, were compared to 10 patients with verified bronchial asthma and 28 healthy controls. RESULTS: The patients with asthma-like symptoms reacted with cough in a dose-dependent way. The number of coughs was significantly greater than in asthmatic patients and healthy controls. The latter two groups did not differ significantly. CONCLUSIONS: The capsaicin provocation test may be a valuable method for showing not only a greater cough sensitivity, but also asthma-like symptoms. The pathophysiology underlying the symptoms may be related to increased sensitivity of free, overactive nerve endings in the respiratory mucosa. Therefore, we suggest that this overreaction in the lower airways be called "sensory hyperreactivity".
E Millqvist; M Bende; O Löwhagen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  53     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1208-12     Citation Subset:  IM    
Asthma and Allergy Centre, University of Gothenburg, Sahlgrenska University Hospital, Sweden.
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MeSH Terms
Asthma / diagnosis,  etiology*
Bronchial Hyperreactivity / complications*,  diagnosis
Bronchial Provocation Tests
Capsaicin / diagnostic use
Cough / chemically induced,  etiology*
Dose-Response Relationship, Drug
Middle Aged
Osmolar Concentration
Reference Values
Sensation Disorders / complications*,  diagnosis
Reg. No./Substance:

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