Document Detail


Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.
MedLine Citation:
PMID:  19634950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in cannabis users. Seventeen heavy cannabis users and 16 cannabis naïve controls participated. Analyses included P50 amplitudes, and time-frequency analyses (event-related spectral perturbations, ERSPs; intertrial coherence, ITC). Consistent with prior studies, cannabis users exhibited reduced P50 gating. The ERSP analysis yielded attenuated high frequency activity in the beta range (13-29 Hz) post-S1 and in the gamma range (30-50 Hz) post-S2 in the cannabis group, compared with the control group. Greater levels of cannabis use were positively associated with high P50 ratios and negatively with post-S2 ERSP gamma power. Findings suggest that heavy cannabis use is associated with aberrant beta and gamma activity in the dual-click procedure, which corroborates recent work demonstrating disruption of beta/gamma by cannabinoid receptor (CB1) agonists in a rat analogue of this task and highlights the translational potential of the dual-click procedure [corrected]
Authors:
Chad R Edwards; Patrick D Skosnik; Adam B Steinmetz; Brian F O'Donnell; William P Hetrick
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  123     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-11-06     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  894-904     Citation Subset:  IM    
Copyright Information:
2009 APA, all rights reserved
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Analysis of Variance
Auditory Perception / drug effects*,  physiology*
Brain / drug effects*,  physiopathology*
Electroencephalography
Evoked Potentials, Auditory
Female
Humans
Interview, Psychological
Male
Marijuana Abuse / physiopathology*
Questionnaires
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
1 R03 DA019630-01/DA/NIDA NIH HHS; 1 R21 DA023097-01A1/DA/NIDA NIH HHS; R03 DA019630/DA/NIDA NIH HHS; R03 DA019630-01A1/DA/NIDA NIH HHS; R21 DA023097/DA/NIDA NIH HHS; R21 DA023097-01A1/DA/NIDA NIH HHS; T32 DA024628/DA/NIDA NIH HHS
Comments/Corrections
Erratum In:
Behav Neurosci. 2009 Oct;123(5):1065

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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