| Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations. | |
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MedLine Citation:
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PMID: 19634950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in cannabis users. Seventeen heavy cannabis users and 16 cannabis naïve controls participated. Analyses included P50 amplitudes, and time-frequency analyses (event-related spectral perturbations, ERSPs; intertrial coherence, ITC). Consistent with prior studies, cannabis users exhibited reduced P50 gating. The ERSP analysis yielded attenuated high frequency activity in the beta range (13-29 Hz) post-S1 and in the gamma range (30-50 Hz) post-S2 in the cannabis group, compared with the control group. Greater levels of cannabis use were positively associated with high P50 ratios and negatively with post-S2 ERSP gamma power. Findings suggest that heavy cannabis use is associated with aberrant beta and gamma activity in the dual-click procedure, which corroborates recent work demonstrating disruption of beta/gamma by cannabinoid receptor (CB1) agonists in a rat analogue of this task and highlights the translational potential of the dual-click procedure [corrected] |
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Authors:
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Chad R Edwards; Patrick D Skosnik; Adam B Steinmetz; Brian F O'Donnell; William P Hetrick |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioral neuroscience Volume: 123 ISSN: 1939-0084 ISO Abbreviation: Behav. Neurosci. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-28 Completed Date: 2009-11-06 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 894-904 Citation Subset: IM |
Copyright Information:
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2009 APA, all rights reserved |
Affiliation:
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Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 21455, USA. chadredwards@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Analysis of Variance Auditory Perception / drug effects*, physiology* Brain / drug effects*, physiopathology* Electroencephalography Evoked Potentials, Auditory Female Humans Interview, Psychological Male Marijuana Abuse / physiopathology* Questionnaires Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1 R03 DA019630-01/DA/NIDA NIH HHS; 1 R21 DA023097-01A1/DA/NIDA NIH HHS; R03 DA019630/DA/NIDA NIH HHS; R03 DA019630-01A1/DA/NIDA NIH HHS; R21 DA023097/DA/NIDA NIH HHS; R21 DA023097-01A1/DA/NIDA NIH HHS; T32 DA024628/DA/NIDA NIH HHS |
| Comments/Corrections | |
Erratum In:
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Behav Neurosci. 2009 Oct;123(5):1065 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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