Document Detail


Sensory ganglionopathy due to gluten sensitivity.
MedLine Citation:
PMID:  20837968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Gluten sensitivity can engender neurologic dysfunction, one of the two commonest presentations being peripheral neuropathy. The commonest type of neuropathy seen in the context of gluten sensitivity is sensorimotor axonal. We report 17 patients with sensory ganglionopathy associated with gluten sensitivity.
METHODS: This is a retrospective observational case series of 17 patients with sensory ganglionopathy and gluten sensitivity. All patients had been followed up for a number of years in dedicated gluten sensitivity/neurology and neuropathy clinics.
RESULTS: Out of a total of 409 patients with different types of peripheral neuropathies, 53 (13%) had clinical and neurophysiologic evidence of sensory ganglionopathy. Out of these 53 patients, 17 (32%) had serologic evidence of gluten sensitivity. The mean age of those with gluten sensitivity was 67 years and the mean age at onset was 58 years. Seven of those with serologic evidence of gluten sensitivity had enteropathy on biopsy. Fifteen patients went on a gluten-free diet, resulting in stabilization of the neuropathy in 11. The remaining 4 had poor adherence to the diet and progressed, as did the 2 patients who did not opt for dietary treatment. Autopsy tissue from 3 patients demonstrated inflammation in the dorsal root ganglia with degeneration of the posterior columns of the spinal cord.
CONCLUSIONS: Sensory ganglionopathy can be a manifestation of gluten sensitivity and may respond to a strict gluten-free diet.
Authors:
M Hadjivassiliou; D G Rao; S B Wharton; D S Sanders; R A Grünewald; A G B Davies-Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  75     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-10-08     Revised Date:  2011-08-19    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1003-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK. m.hadjivassiliou@sheffield.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Aged
Aged, 80 and over
Ataxia / etiology,  physiopathology
Biopsy
Celiac Disease / diet therapy,  pathology
Diet
Diet, Gluten-Free
Female
Food Hypersensitivity / complications*,  diet therapy,  immunology
Ganglia, Sensory / pathology*
Gliadin / immunology
Glutens / adverse effects*,  immunology
Humans
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Male
Middle Aged
Peripheral Nervous System Diseases / etiology*,  immunology,  pathology
Grant Support
ID/Acronym/Agency:
//Medical Research Council
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 8002-80-0/Glutens; 9007-90-3/Gliadin
Comments/Corrections
Comment In:
Neurology. 2011 Jul 5;77(1):87; author reply 87   [PMID:  21727269 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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