Document Detail


Sensory axonal dysfunction in cervical radiculopathy.
MedLine Citation:
PMID:  25143629     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to evaluate changes in sensory axonal excitability in the distal nerve in patients with cervical radiculopathy.
METHODS: The patients were classified by the findings of cervical MRI into two subgroups: 22 patients with C6/7 root compression and 25 patients with cervical cord and root compression above/at C6/7. Patients were investigated using conventional nerve conduction studies (NCS) and nerve excitability testing. Sensory nerve excitability testing was undertaken with stimulation at the wrist and recording from digit II (dermatome C6/7). The results were compared with healthy controls. Both preoperative and postoperative tests were performed if the patient underwent surgery.
RESULTS: Sensory axonal excitability was significantly different in both cohorts compared with healthy controls, including prolonged strength-duration time constant, reduced S2 accommodation, increased threshold electrotonus hyperpolarisation (TEh (90-100 ms)), and increased superexcitability. The changes in these excitability indices are compatible with axonal membrane hyperpolarisation. In five patients who underwent surgery, the postoperative sensory excitability was tested after 1 week, and showed significant changes in TE (TEh (90-100 ms) and TEh slope, p<0.05) between presurgery and postsurgery.
CONCLUSIONS: The present study demonstrated distal nerve axonal hyperpolarisation in patients with cervical radiculopathy. These findings suggest that the hyperpolarised pattern might be due to Na(+)-K(+) ATPase overactivation induced by proximal ischaemia, or could reflect the remyelinating process. Distal sensory axons were hyperpolarised even though there were no changes in NCS, suggesting that nerve excitability testing may be more sensitive to clinical symptoms than NCS in patients with cervical radiculopathy.
Authors:
Jia-Ying Sung; Jowy Tani; Kuo-Sheng Hung; Tai-Ngar Lui; Cindy Shin-Yi Lin
Related Documents :
25487629 - Ventricular morphology is a determinant of diastolic performance in patients with singl...
9126899 - Effect of transluminal angioplasty on cerebral blood flow in the management of symptoma...
25243619 - Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic gvhd of the skin ...
25316229 - Correlation of th17 cells and cd4(+)cd25(+) regulatory t cells with clinical parameters...
25185419 - Evaluation of chromium and manganese in biological samples (scalp hair, blood and urine...
25392319 - Prognostic biomarkers of ifnb therapy in multiple sclerosis patients.
20171599 - Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy ...
3042939 - Efficacy of pancrease: crossover comparative study versus eurobiol in cystic fibrosis.
11817709 - Direct measurement of igf-i and igfbp-3 in bronchoalveolar lavage fluid from idiopathic...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-20
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  -     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of blood flow in the retinal trilaminar vascular network.
Next Document:  SANDO syndrome in a cohort of 107 patients with CPEO and mitochondrial DNA deletions.