Document Detail

Sensory Neuropathy With Sjögren's Syndrome, Thymoma, and Hypogammaglobulinemia.
MedLine Citation:
PMID:  19078556     Owner:  NLM     Status:  In-Data-Review    
We report a 63-year-old woman with common variable immunodeficiency (CVID) and an indolent distal sensory neuropathy. Despite having negative serologic tests for Sjögren's syndrome, evaluation of the neuropathy led to a new diagnosis of Sjögren's syndrome based on the presence of sicca symptoms, an abnormal Schirmer's test, and histologic evidence of sialadenitis. In addition, a thymoma was discovered. We conclude that the occurrence of thymoma, CVID, and Sjogren's syndrome reflect a state of systemic autoimmune dysregulation in this patient. We also reiterate the diagnostic importance of salivary gland biopsy in patients with sicca symptoms and sensory neuropathy.
D Lacomis; C V Oddis; M J Giuliani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuromuscular disease     Volume:  1     ISSN:  1522-0443     ISO Abbreviation:  J Clin Neuromuscul Dis     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887391     Medline TA:  J Clin Neuromuscul Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  -    
From the Department of *Neurology.daggerPathology(Neuropathology),and double daggerMedicine (Rheumatology & Clinical Immunology), University of Pittsburgh School of Medicine, Pittsburgh. PA.
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