Document Detail


Sensory and motor characterization in the postnatal valproate rat model of autism.
MedLine Citation:
PMID:  22627078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although autism is diagnosed according to three core features of social deficits, communication impairments, and repetitive or stereotyped behaviors, other behavioral features such as sensory and motor impairments are present in more than 70% of individuals with autism spectrum disorders (ASD). Exposure of rat pups to the teratogen valproate during sensitive periods of brain development has been shown to elicit behavioral features associated with autism diagnosis and has been proposed as a valid animal model of the disorder. The purpose of this study was to characterize sensory and motor performance in rats postnatally treated with valproate. Thirty-four rat pups were injected with either valproate (150 mg/kg) or saline on postnatal days 6-12. Auditory and tactile startle as well as auditory sensory gating was assessed during both the juvenile and adolescent stages of development; motor testing was conducted during late adolescence and included a sunflower seed eating task and a vermicelli handling task. Valproate-treated rats were underresponsive to auditory stimuli, showed deficits in auditory sensory gating, and demonstrated impairments in motor speed and performance. These findings suggest that postnatal valproate treatment elicits sensory and motor features often seen in individuals with ASD. Further, the hyposensitivity seen in postnatally valproate-treated rats contrasted with hypersensitivity previously reported in prenatally valproate-exposed rats. This suggests that timing of teratogenic exposure during early brain development may be important to consider when investigating the neurobiological basis of sensorimotor impairments in ASD.
Authors:
Stacey Reynolds; Alexandre Millette; Darragh P Devine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-24
Journal Detail:
Title:  Developmental neuroscience     Volume:  34     ISSN:  1421-9859     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-20     Completed Date:  2013-02-22     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  258-67     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Occupational Therapy, Virginia Commonwealth University, Richmond, VA 23298, USA. reynoldsse3@vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Autistic Disorder / physiopathology*
Behavior, Animal / drug effects*
Disease Models, Animal*
Feeding Behavior / drug effects
Female
GABA Agents / pharmacology*
Male
Rats
Rats, Long-Evans
Sensory Gating / drug effects*
Startle Reaction / drug effects*
Valproic Acid / pharmacology*
Grant Support
ID/Acronym/Agency:
K12 HD055929/HD/NICHD NIH HHS; K12 HD055929/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/GABA Agents; 99-66-1/Valproic Acid
Comments/Corrections

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