Document Detail


A sensory code for host seeking in parasitic nematodes.
MedLine Citation:
PMID:  21353558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parasitic nematode species often display highly specialized host-seeking behaviors that reflect their specific host preferences. Many such behaviors are triggered by host odors, but little is known about either the specific olfactory cues that trigger these behaviors or the underlying neural circuits. Heterorhabditis bacteriophora and Steinernema carpocapsae are phylogenetically distant insect-parasitic nematodes whose host-seeking and host-invasion behavior resembles that of some devastating human- and plant-parasitic nematodes. We compare the olfactory responses of Heterorhabditis and Steinernema infective juveniles (IJs) to those of Caenorhabditis elegans dauers, which are analogous life stages. The broad host range of these parasites results from their ability to respond to the universally produced signal carbon dioxide (CO(2)), as well as a wide array of odors, including host-specific odors that we identified using thermal desorption-gas chromatography-mass spectroscopy. We find that CO(2) is attractive for the parasitic IJs and C. elegans dauers despite being repulsive for C. elegans adults, and we identify a sensory neuron that mediates CO(2) response in both parasitic and free-living species, regardless of whether CO(2) is attractive or repulsive. The parasites' odor response profiles are more similar to each other than to that of C. elegans despite their greater phylogenetic distance, likely reflecting evolutionary convergence to insect parasitism.
Authors:
Elissa A Hallem; Adler R Dillman; Annie V Hong; Yuanjun Zhang; Jessica M Yano; Stephanie F DeMarco; Paul W Sternberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-25
Journal Detail:
Title:  Current biology : CB     Volume:  21     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-07-12     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Bayes Theorem
Biological Evolution*
Carbon Dioxide / metabolism
Chemotaxis / physiology*
Gas Chromatography-Mass Spectrometry
Host-Parasite Interactions / physiology*
Insects / parasitology*
Life Cycle Stages / physiology
Likelihood Functions
Models, Genetic
Molecular Sequence Data
Odors*
Phylogeny*
RNA, Ribosomal / genetics
Rhabditida / genetics,  physiology*
Sequence Analysis, DNA
Smell / physiology
Species Specificity
Grant Support
ID/Acronym/Agency:
R00 AI085107/AI/NIAID NIH HHS; T32 GM007616/GM/NIGMS NIH HHS; T32 GM007616-33/GM/NIGMS NIH HHS; T32GM07616/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/RNA, Ribosomal; 142M471B3J/Carbon Dioxide
Comments/Corrections

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