| Sensors made of RNA: tailored ribozymes for detection of small organic molecules, metals, nucleic acids and proteins. | |
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MedLine Citation:
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PMID: 16671821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acids are well suited to serve as biosensors for the fast and reliable detection of small organic molecules, such as a number of metabolites or antibiotics, specific nucleic acid sequences, peptides, proteins or metal ions. One of the main advantages of using nucleic acids as biosensors is that they can be modulated to respond allosterically to specific effectors. Thus molecular recognition is transformed directly into a catalytic process with observable results. In particular, catalytic RNA structures, such as the hammerhead and hairpin ribozymes, have been used for biosensor engineering. The review reports on the function mode of nucleic acid biosensors and introduces recent developments and applications in the field. |
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Authors:
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S Müller; D Strohbach; J Wolf |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: IEE proceedings. Nanobiotechnology Volume: 153 ISSN: 1478-1581 ISO Abbreviation: IEE Proc Nanobiotechnol Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-04 Completed Date: 2006-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101188789 Medline TA: IEE Proc Nanobiotechnol Country: England |
Other Details:
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Languages: eng Pagination: 31-40 Citation Subset: IM |
Affiliation:
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Ruhr-Universitat Bochum, Fakultat Chemie, Universitatsstrasse 150, D-44780 Bochum, Germany. sabine.w.mueller@rub.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques
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instrumentation,
methods* Equipment Design Metals / analysis* Microchemistry / methods* Nucleic Acids / analysis Organic Chemicals / analysis* Proteins / analysis* RNA / analysis, chemistry* RNA, Catalytic / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Nucleic Acids; 0/Organic Chemicals; 0/Proteins; 0/RNA, Catalytic; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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